---

8. References and Footnotes

[1] D. J. Cram, J. M. Cram, Science, 1974, 183, 803-809; D. J. Cram, Angew. Chem. Int. Ed. Engl., 1988, 27, 1009-1020; C. J. Pedersen, Angew. Chem. Int. Ed. Engl., 1988, 27, 1021-1027.

[2] J.-M. Lehn, Acc. Chem. Res., 1978, 11, 49-57; J.-M. Lehn, Pure Appl. Chem., 1978, 50, 871-892; J.-M. Lehn, Science, 1985, 227, 849-856; J.-M. Lehn, Angew. Chem. Int. Ed. Engl., 1988, 27, 89-112.

[3] C. J. Suckling, J. Chem. Soc., Chem. Commun., 1982, 661-662.

[4] J. A. Hyatt, J. Org. Chem., 1978, 43, 1808-1811; F. Vögtle, E. Weber, Angew. Chem. Int. Ed. Engl., 1974, 13, 814-815.

[5] Y. Murakami, A. Nakano, K. Akiyoshi, K. Fukuya, J. Chem. Soc., Perkin Trans 1, 1981, 2800-2808.

[6] E. Buhleier, W. Wehner, F. Vögtle, Synthesis, 1978, 155-158.

[7] R. Moors, F. Vögtle, Chem. Ber., 1993, 126, 2133-2135; C. Wörner, R. Mülhaupt, Angew. Chem. Int. Ed. Engl., 1993, 32, 1306-1308; E. M. M. de Brabander-van den Berg, E. W. Meijer, Angew. Chem. Int. Ed. Engl., 1993, 32, 1308-1311.

[8] D. A. O'Sullivan, C & EN, 1993, August 16, 20-23.

[9] P. J. Flory, J. Am. Chem. Soc., 1952, 74, 2718-2723.

[10] M. Maciejewski, J. Macromol. Sci. Chem., 1982, A17(4), 689-703; W. Burchard, K. Kajiwara, D. Nerger, J. Polym. Sci., Phys. Ed., 1982, 20, 157-171; S. Alexander, R. Orbach, J. Phys. Lett., 1982, 43, 625-631.

[11] P. G. de Gennes, H. Hervet, J. Physique - Lettres, 1983, 351-360.

[12] D. A. Tomalia, H. Baker, J. Dewald, M. Hall, G. Kallos, S. Martin, J. Roeck, J. Ryder, P. Smith, Polym. J., 1985, 17, 117-132; D. A. Tomalia, H. Baker, J. Dewald, M. Hall, G. Kallos, S. Martin, J. Roeck, J. Ryder, P. Smith, Macromolecules, 1986, 19, 2466-2468; D. A. Tomalia, M. Hall, D. Hedstrand, J. Am. Chem. Soc., 1987, 109, 1601-1603; D. A. Tomalia, V. Berry, M. Hall, D. M. Hedstrand, Macromolecules, 1987, 20, 1164-1167; D. A. Tomalia et al. US Pat., 4 587 392 (1986), 4 558 120 (1985), 4 568 737 (1986), 4 599 400, 4 631337 (1986), 4 507 466 (1985), For an extensive review, see: D. A. Tomalia, A. M. Naylor, W. A. Goddard III, Angew. Chem. Int. Ed. Engl., 1990, 29, 138-175.

[13] R. G. Denkewalter, J. Kolc, W. J. Lukasavage, US Pat., 1981, 4 289 872.

[14] The term 'starburst' is a trademark of the Dow Chemical Company.

[15] The term 'dendrimer' can be traced back to A. J. Vogel.

[16] A rigorous definition of the term 'dendrimer' is not clear. Different research groups have attached different meanings to it. What seems generally accepted is that dendrimers are highly branched and essentially monodisperse - although some divergently grown dendrimers have some polydispersity as a consequence of incomplete reactions. Some researchers would argue that a true dendrimer has a degree of branching (Dbr) of 1, but others have the more relaxed view that monodispersity is sufficient. In the latter case, a hyperbranched polymer could be trivially considered a mixture of dendrimers. Further criteria, such as numbers of generations and identical constitiutions for generations, have been discussed lightheartedly.

[17] G. R. Newkome, Z. Yao, G. R. Baker, V. K. Gupta, J. Org. Chem., 1985, 50, 2004-2006; G. R. Newkome, Z. Yao, G. R. Baker, V. K. Gupta, P. S. Russo, M. J. Saunders, J. Am. Chem. Soc., 1986, 108, 849-850.

[18] G. R. Newkome, G. R. Baker, M. J. Saunders, P. S. Russo, V. K. Gupta, Z. Yao, J. E. Miller, K. Bouillion, J. Chem. Soc., Chem. Commun., 1986, 752-753.

[19] The term 'arborol' is derived from the Greek arbor, meaning branch.

[20] A. M. Naylor, W. A. Goddard III, G. E. Kiefer, D. A. Tomalia, J. Am. Chem. Soc., 1989, 111, 2339-2341.

[21] M. L. Mansfield, L. I. Klushin, Macromolecules, 1993, 26, 4262-4268; M. Murat, G. S. Grest, Macromolecules, 1996, 29, 1278-1285.

[22] C. Steel, F. Vögtle, Angew. Chem. Int. Ed. Engl., 1992, 31, 528-549; M. Maciejewski, J. Macromol. Sci. Chem., 1982, A17(4), 689-703.

[23] N. Ardoin, D. Astruc, Bull. Soc. Chim. Fr., 1995, 132, 875-909; D. A. Tomalia, P. R. Dvornic, Nature (London), 1994, 372, 617-618; R. F. Service, Science, 1995, 267, 458-459; J. Alper, Chem. Ind., 1991, 268-269.

[24] C. J. Hawker, K. L. Wooley, J. M. J. Fréchet, J. Chem. Soc. Perkin Trans. 1, 1993, 1287-1297.

[25] D. A. Tomalia, D. A. Kaplan, W. J. Kruper, R. C. Cheng, I. A. Tomlinson, M. J. Fazio, D. M. Hedstrand, L. R. Wilson, C. W. Jung, D. S. Edwards, US Pat., 1994, 5338532.

[26] E. M. M. de Brabander, J. A. Put, Proceedings of the American Chemical Society Division of Polymeric Materials: Science and Engineering, 1995, 73, 79.

[27] E. C. Wiener, M. W. Brechbiel, H. Brothers, R. L. Magin, O. A. Gansow, D. A. Tomalia, P. C. Lauterbur, Magn. Res. Med., 1994, 31, 1-8.

[28] G. R. Newkome, G. R. Baker, J. K. Young, J. G. Traynham, J. Polym. Sci., Polym. Chem., 1993, A31, 641-651; G. R. Newkome, G. R. Baker, Polym. Prepr. (Am. Chem. Soc. Div. Polym. Chem.), 1994, 35, 6.

[29] Z. Xu, M. Kahr, K. L. Walker, C. L. Wilkins, J. S. Moore, J. Am. Chem. Soc., 1994, 116, 4537-4550.

[30] A. B. Padias, H. K. Hall Jr, D. A. Tomalia, J. R. McConnel, J. Org. Chem., 1987, 52, 5305-5312.

[31] J. M. J. Fréchet, C. J. Hawker, K. L. Wooley, J. M. S. Pure Appl. Chem., 1994, A31(11), 1627-1645.

[32] R. H. E. Hudson, M. J. Damha, J. Am. Chem. Soc., 1993, 115, 2119-2124.

[33] R. Roy, D. Zanini, S. J. Meunier, A. Romanowska, J. Chem. Soc., Chem. Commun., 1993, 1869-1872.

[34] S. Achar, R. J. Puddephatt, J. Chem. Soc., Chem. Commun., 1994, 1895-1896; S. Achar, R. J. Puddephatt, Organometallics, 1995, 14, 1681-1687.

[35] S. Campagna, G. Denti, S. Serroni, A. Juris, M. Venturi, V. Ricevuto, V. Balzani, Chem. Eur. J., 1995, 1, 211-221.

[36] H. Uchida, Y. Kabe, K. Yoshino, A. Kawamata, T. Tsumuraya, S. Masumune, J. Am. Chem. Soc., 1990, 112, 7077-7079; L. J. Mathias, T. W. Carothers, J. Am. Chem. Soc., 1991, 113, 4043-4044.

[37] D. Seyferth, D. Y. Son, A. L. Rheingold, R. L. Ostrander, Organometallics, 1994, 13, 2682-2690.

[38] N. Launay, A.-M. Caminade, J.-P. Majoral, J. Am. Chem. Soc., 1995, 117, 3282-3283; K. Rengan, R. Engel, J. Chem. Soc. Perkin Trans. 1, 1991, 987 990.

[39] F. Sournies, F. Crasnier, M. Graffeuil, J.-P. Faucher, R. Lahana, M. C. Labarre, J.-F. Labarre, Angew. Chem. Int. Ed. Engl., 1995, 34, 578-581.

[40] A. Rajca, S. Utampanya, J. Am. Chem. Soc., 1993, 115, 10688-10694; Z. Xu, J. S. Moore, Angew. Chem. Int. Ed. Engl., 1993, 32, 246-248.

[41] H.-B. Mekelburger, W. Jaworek, F. Vögtle, Angew. Chem. Int. Ed. Engl., 1992, 31, 1571-1576; G. R. Newkome, C. N. Moorefield, G. R. Baker, Alrichimica Acta, 1992, 25, 31-38; D. A. Tomalia, Adv. Mater., 1994, 6, 529-539; G. R. Newkome, C. N. Moorefield (Ed.: D. N. Reinhoudt) in Comprehensive Supramolecular Chemistry vol. 10, Pergamon, Oxford, UK, 1996, 777-832; J. M. J. Fréchet, C. J. Hawker (Ed.: S. L. Aggarwal, S. Russo) in Comprehensive Polym. Sci., 1996, 140-201.

[42] For a detailed analysis of imperfections and molecular weight distribution in the PAMAM series, see: M. L. Mansfield, Macromolecules, 1993, 26, 3811-3814.

[43] C. J. Hawker, J. M. J. Fréchet, J. Chem. Soc., Chem. Commun., 1990, 1010 1013; C. J. Hawker, J. M. J. Fréchet, J. Am. Chem. Soc., 1990, 112, 7638-7647; K. E. Uhrich, J. M. J. Fréchet, J. Chem. Soc. Perkin Trans., 1992, 1623-1630; T. M. Miller, T. X. Neenan, Chem. Mater., 1990, 2, 346-349; T. M. Miller, T. X. Neenen, R. Zayas, H. E. Bair, J. Am. Chem. Soc., 1992, 114, 1018-1025.

[44] The 'focal point' of a dendritic 'wedge' is the single functional group from where the branches eminate.

[45] K. L. Wooley, C. J. Hawker, J. M. J. Fréchet, J. Am. Chem. Soc., 1991, 113, 4252-4261.

[46] K. L. Wooley, C. J. Hawker, J. M. J. Fréchet, Angew. Chem. Int. Ed. Engl., 1994, 33, 82-85. The 'branched monomer' may better be considered a trimer as it is composed of three linked branching units. It has been pointed out that the 'branched monomer' could be polymerised, and thus can be called a monomer. This review will refer to such species as oligomers in order to avoid confusion.

[47] T. Kawaguchi, K. L. Walker, C. L. Wilkins, J. S. Moore, J. Am. Chem. Soc., 1995, 117, 2159-2165.

[48] D. L. Pearson, J. S. Schumm, J. M. Tour, Macromolecules, 1994, 27, 2348 2350; J. M. Tour, Chem. Rev., 1996, 96, 537-553.

[49] T. Nagasaki, M. Ukon, S. Arimori, S. Shinkai, J. Chem. Soc., Chem. Commun., 1992, 608-610; T. Nagasaki, O. Kimura, M. Ukon, S. Arimori, I. Hamachi, S. Shinkai, J. Chem. Soc. Perkin Trans. 1, 1994, 75-81.

[50] J. M. J. Fréchet, I. Gitsov, R. B. Grubbs, C. J. Hawker, M. Hemni, M. Leduc, E. Sanford, K. Yui, Proceedings of the American Chemical Society Division of Polymeric Materials: Science and Engineering, 1995, 73, 271-272.

[51] H.-T. Cheang, C.-T. Chen, T. Kondo, G. Siuzdak, K. B. Sharpless, Angew. Chem. Int. Ed. Engl., 1996, 35, 182-186.

[52] D. Zanini, R. Roy, J. Org. Chem. 1996, 61, 7348-7354.

[53] R. Klopsch, P. Franke, A.-D. Schlüter, Chem. Eur. J., 1996, 2, 1330-1334.

[54] R. Spindler, J. M. J. Fréchet, J. Chem. Soc. Perkin Trans. 1, 1993, 913-918.

[55] S. R. Turner, Proceedings of the American Chemical Society Division of Polymeric Materials: Science and Engineering, 1995, 73, 77-78, and references cited therin; J. M. J. Fréchet, C. J. Hawker, Reactive & Functional Polymers, 1995, 26, 127-136.

[56] The degree of branching is defined as the fraction of branching units in a structure which have reacted at all or none of their surface functions. A perfect dendrimer therefore has a Dbr of 1, although a monodisperse sample of a carefully engineered dendrimer may have a lower value. These values can be experimentally determined. The important difference between dendrimers and hyperbranched polymers is not Dbr, but the level of polydispersity.

[57] G. R. Newkome, C. N. Moorefield, J. M. Keith, G. R. Baker, G. H. Escamilla, Angew. Chem. Int. Ed. Engl., 1994, 33, 666-668.

[58] C. J. Hawker, J. M. J. Fréchet, J. Chem. Soc. Perkin Trans. 1, 1992, 2459-2469.

[59] J. F. G. A. Jansen, R. A. J. Janssen, E. M. M. de Brabander-van den Berg, E. W. Meijer, Adv. Mater., 1995, 7, 561-564; J. F. G. A. Jansen, E. M. M. de Brabander-van den Berg, E. W. Meijer, Science, 1994, 266, 1226-1229; J. F. G. A. Jansen, E. W. Meijer, J. Am. Chem. Soc., 1995, 117, 4417-4418.

[60] G. R. Newkome, V. V. Narayanan, A. K. Patri, J. Gross, C. N. Moorefield, G. R. Baker, Proceedings of the American Chemical Society Division of Polymeric Materials: Science and Engineering, 1995, 73, 222-223.

[61] For instance, the cyclophane host cores of 'dendrophanes': P. Walliman, P. Seiler, F. Diederich, Helv. Chim. Acta, 1996, 79, 779-788.

[62] R.-H. Jin, T. Aida, S. Inoue, J. Chem. Soc., Chem. Commun., 1993, 1260 1262.

[63] P. Bhyrappa, J. K. Young, J. S. Moore, K. S. Suslick, J. Am. Chem. Soc., 1996, 118, 5708-5711.

[64] D.-L. Jiang, T. Aido, J. Chem. Soc., Chem. Commun., 1996, 1523-1524.

[65] P. J. Dandliker, F. Diedrich, M. Gross, C. B. Knobler, A. Louati, E. M. Sanford, Angew. Chem. Int. Ed. Engl., 1994, 33, 1739-1742; For another 'Dendritic model of a redox protein', see H.-F. Chow, I. Y.-K. Chan, D. T. W. Chan, R. W. M. Kwok, Chem. Eur. J., 1996, 2, 1085-1091.

[66] D. Seebach, J.-M. Lapierre, K. Skobridis, G. Greiveldinger, Angew. Chem. Int. Ed. Engl., 1994, 33, 440-442.

[67] C. J. Hawker, K. L. Wooley, J. M. J. Fréchet, J. Am. Chem. Soc., 1993, 115, 4375-4376.

[68] L. J. Twyman, A. E. Beezer, J. C. Mitchell, Tetrahedron Lett., 1994, 35, 4423-4424; D. V. McGrath, M.-J. Wu, U. Chaudhry, Tetrahedron Lett., 1996, 37, 6077-6080.

[69] H.-F. Chow, C. C. Mak, J. Chem. Soc. Perkin Trans. 1, 1994, 2223-2228.

[70] V. Percec, P. Chu, Proceedings of the American Chemical Society Division of Polymeric Materials: Science and Engineering, 1995, 73, 125-126.

[71] For another example of a dendrimer as a light-harvesting antenna, see: G. M. Stuart, M. A. Fox, J. Am. Chem. Soc., 1996, 118, 4354-4360.

[72] A. Miedaner, C. J. Curtis, R. M. Barkley, D. L. DuBois, Inorg. Chem., 1994, 33, 5428-5490.

[73] M. R. Bryce, W. Davenport, A. J. Moore, Angew. Chem. Int. Ed. Engl., 1994, 33, 1761-1762.

[74] H. Frey, R. Mülhaupt, K. Lorenz, U. Rapp, F. J. Mayer-Posner, Proceedings of the American Chemical Society Division of Polymeric Materials: Science and Engineering, 1995, 73, 127-128.

[75] G. R. Newkome, X. Lin, C. D. Weis, Tetrahedron: Asymmetry, 1991, 2, 957 960.

[76] D. Zanini, W. K. C. Park, S. J. Meunier, Q. Wu, S. Aravind, B. Kratzer, R. Roy, Proceedings of the American Chemical Society Division of Polymeric Materials: Science and Engineering, 1995, 73, 82-83; R. Roy, W. K. C. Park, Q. Wu, S.-N. Wang, Tetrahedron Lett., 1995, 36, 4377-4380; T. K. Lindhorst, C. Kieburg, Angew. Chem. Int. Ed. Engl., 1996, 35, 1953-1956.

[77] P. R. Ashton, S. E. Boyd, C. L. Brown, N. Jayaraman, S. A. Nepogodiev, J. F. Stoddart, Chem. Eur. J., 1996, 2, 1115-1128.

[78] Y.-H. Liao, J. R. Moss, Organometallics, 1995, 14, 2130-2132.

[79] G. van Koten, D. M. Grove, Proceedings of the American Chemical Society Division of Polymeric Materials: Science and Engineering, 1995, 73, 228-229.

[80] J. F. G. A. Jansen, E. M. M. de Brabander-van den Berg, E. W. Meijer, Science, 1994, 266, 1226-1229; J. F. G. A. Jansen, H. W. I. Peerlings, E. M. M. de Brabander-van den Berg, E. W. Meijer, Angew. Chem. Int. Ed. Engl., 1995, 34, 1206-1209.

[81] K.E. Drexler, Proc. Natl. Acad. Sci. USA 1981, 78, 5275-5278 and references cited therein; K.E. Drexler, Nanosystems Molecular Machinery, Manufacturing and Computation, Wiley Interscience, New York, 1992; J. A. Preece, J. F. Stoddart, Nanobiology 1994, 3, 149-166; G. A. Ozin, Adv. Mater. 1992, 4, 612-649; G. Walker, New Scientist 1995, 28-31; C. A. Rogers, Sci. Am. 1995, 122-127; D. Bradley, Chem. Soc. Rev. 1995, 24, 379-382.

[82] K. L. Wooley, C. J. Hawker, J. M. J. Fréchet, J. Chem. Soc. Perkin Trans. 1, 1991, 1059-1076; C. J. Hawker, J. M. J. Fréchet, Macromolecules, 1990, 23, 4726-4729.

[83] C. J. Hawker, J. M. J. Fréchet, J. Am. Chem. Soc., 1992, 114, 8405-8413.

[84] J. A. Kremers, E. W. Meijer, J. Org. Chem., 1994, 59, 4262-4266; J. W. J. Knapen, A. W. van der Made, P. W. N. M. van Leeuwen, P. Wijkens, D. M. Grove, G. van Koten, Nature (London), 1994, 372, 659-663.

[85] A 'segment-block copolymer' is a term used (ref. 83) to describe dendrimers where segments are of different constitutions, such as the chiral pentaerithritol-based dendrimer described in ref. 84.

[86] A 'layer-block copolymer' is a term used (ref. 83) to describe dendrimers where layers (generations) are of different constitutions, such as the early dendrimers synthesised by Newkome (ref. 17,18).

[87] D. A. Tomalia, D. M. Hedstrand, M. S. Ferrito, Macromolecules, 1991, 24, 1435-1438; A.-D. Schlüter, W. Claussen, E. Amoulong-Kirstein, B. Karakaya, Proceedings of the American Chemical Society Division of Polymeric Materials: Science and Engineering, 1995, 73, 226-227; R. Yin, D. R. Swanson, D. A. Tomalia, Proceedings of the American Chemical Society Division of Polymeric Materials: Science and Engineering, 1995, 73, 277-278.

[88] I. Gitsov, J. M. J. Fréchet, Proceedings of the American Chemical Society Division of Polymeric Materials: Science and Engineering, 1995, 73, 129 130.

[89] J. C. M. van Hest, C. Elissen-Román, M. W. P. L. Baars, D. A. P. Delnoye, M. H. P. van Genderen, E. W. Meijer, Proceedings of the American Chemical Society Division of Polymeric Materials: Science and Engineering, 1995, 73, 281-282; J. C. M. van Hest, D. A. P. Delnoye, M. W. P. L. Baars, M. H. P. van Genderen, E. W. Meijer, Science, 1995, 268, 1592-1594.

[90] D. B. Amabilino, P. R. Ashton, C. L. Brown, J. M. J. Fréchet, F. M. Raymo, N. Spencer, J. F. Stoddart, J. Am. Chem. Soc., In press.

[91] C. J. Hawker, K. L. Wooley, J. M. J. Fréchet, J. Chem. Soc., Chem. Commun., 1994, 925-926; K. L. Wooley, C. J. Hawker, J. M. J. Fréchet, F. Wudl, G. Srdanov, S. Shi, C. Li, M. Kao, J. Am. Chem. Soc., 1993, 115, 9836-9837.

[92] S. C. Zimmerman, F. W. Zeng, D. E. C. Reichert, S. V. Kolotuchin, Science, 1996, 271, 1095-1098.

[93] J. S. Lindsey, New J. Chem., 1991, 15, 153-180; D. Philp, J. F. Stoddart, Synlett, 1991, 445-458; G. M. Whitesides, J. P. Mathias, C. T. Seto, Science, 1991, 254, 1312-1319; D. B. Amabilino, J. F. Stoddart, Pure. Appl. Chem., 1993, 65, 2351-2359; D. Philp, J. F. Stoddart, Angew. Chem. Int. Ed. Engl., 1996, 35, 1154-1196.

[94] G. R. Newkome, G. R. Baker, S. Arai, M. J. Saunders, P. S. Russo, K. J. Theriot, C. N. Moorefield, L. E. Rogers, J. E. Miller, T. R. Lieux, M. E. Murray, B. Phillips, L. Pascal, J. Am. Chem. Soc., 1990, 112, 8458-8465; G. R. Newkome, C. N. Moorefield, G. R. Baker, R. K. Behera, G. H. Escamilla, M. J. Saunders, Angew. Chem. Int. Ed. Engl., 1992, 31, 917-919.

[95] A. M. Naylor, W. A. Goddard III, G. E. Kiefer, D. A. Tomalia, J. Am. Chem. Soc., 1989, 111, 2339-2341.

[96] A. B. Padias, H. K. Hall Jr, D. A. Tomalia, J. R. McConnell, J. Org. Chem., 1987, 52, 5305-5312.

[97] T. Higashimura, S. Aoshima, M. Sawamoto, Makromol. Chem. Macromol. Symp., 1988, 13/14, 457-471; T. Higashimura, S. Aoshima, M. Sawamoto, Makromol. Chem. Macromol. Symp., 1988, 13/14, 513-526;

[98] J. W. Leon, J. M. J. Fréchet, Polym. Bull., 1995, 35, 449-455; J. Am. Soc. Mass Spectrom., 1994, 5, 731-739.

[99] P. R. Dvornic, D. A. Tomalia, Macromol. Symp., 1995, 98, 403-428; B. L. Schwartz, A. L. Rockwood, R. D. Smith, D. A. Tomalia, R. Spindler, Rapid Commun. Mass Spectrom., 1995, 9, 1552-1555.

[100] S. S. Sheiko, G. Eckert, G. Ignat'eva, A. M. Muzafarov, J. Spickerman, H. J. Räder, M. Möller, Macromol. Rapid Commun., 1996, 17, 283-297.

[101] R. D. Hester, P. H. Mitchell, J. Polym. Sci. Chem. Ed., 1980, 18, 1727-1738.

[102] B. J. Bauer, R. M. Briber, B. Hammouda, D. A. Tomalia, Abstracts of Papers of the American Chemical Society, 1992, 204, 225-PMSE.

[103] B. J. Bauer, B. Hammouda, J. D. Barnes, R. M. Briber, D. A. Tomalia, Abstracts of Papers of the American Chemical Society, 1994, 208, 383-PMSE.

[104] C. J. Hawker, P. J. Farrington, M. E. Mackay, K. L. Wooley, J. M. J. Fréchet, J. Am. Chem. Soc., 1995, 117, 4409-4410.

[105] K. L. Wooley, C. J. Hawker, J. M. J. Fréchet, Macromolecules, 1993, 26, 1514-1519.

[106] P. R. Dvornic, S. Uppuluri, D. A. Tomalia, Proceedings of the American Chemical Society Division of Polymeric Materials: Science and Engineering, 1995, 73, 131 132.

[107] R. A. J. Janssen, J. F. G. A. Jansen, J. A. E. H. van Haare, E. W. Meijer, Adv. Mater., 1996, 8, 494-500.

[108] G. Caminati, M. F. Ottaviani, K. Gopidas, S. Jockusch, N. J. Turro, D. A. Tomalia, Proceedings of the American Chemical Society Division of Polymeric Materials: Science and Engineering, 1995, 73, 80 81.

[109] F. M. Menger, J. M. Jekunica, J. Am. Chem. Soc., 1978, 100, 688-691.

[110] G. Tong, Y. Pan, M. Afeworki, M. D. Poliks, J. Schaefer, Macromolecules, 1995, 28, 1719-1720.

[111] K. Wooley, C. Klug, T. Kowalewski, J. Schaefer, Proceedings of the American Chemical Society Division of Polymeric Materials: Science and Engineering, 1995, 73, 230-231.

[112] M. F. Ottaviani, S. Bossmann, N. J. Turro, D. A. Tomalia, J. Am. Chem. Soc., 1994, 116, 661-671; M. F. Ottiviani, F. Montalti, M. Romanelli, N. J. Turro, D. A. Tomalia, J. Phys. Chem., 1996, 100, 11033-11042.

[113] These ideas can be read in a large proportion of papers published in the field of dendrimers. They can be traced back as far as the first dendrimer papers published.

[114] K. W. Hahn, W. A. Klis, J. M. Stewart, Science, 1990, 248, 1544-1547.

[115] H. Brunner, J. Organomet. Chem., 1995, 500, 39-46.

[116] J.-J. Lee, W. T. Ford, J. A. Moore, Y. Li, Macromolecules, 1994, 27, 4632-4634.

[117] C. Bolm, N. Derrien, A. Seger, Synlett, 1996, 387-388; D. J. Evans, A. Kanasagooriam, A. Williams, J. Mol. Catal., 1993, 85, 21-32.

[118] K. Matyjaszewski, T. Shigemoto, J. M. J. Fréchet, M. Leduc, Macromolecules, 1996, 29, 4167-4171; I. Gitsov, P. T. Ivanova, J. M. J. Fréchet, Makromol. Chem., Rapid Commun., 1994, 15, 387-393.